Protein Purification
MilliporeSigma™ Calbiochem™ APT1 Inhibitor II, Cpd21
A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma pr
MilliporeSigma™ Calbiochem™ IRE1 Inhibitor IV, KIRA6
KIRA6, IRE1a Kinase Inhibitor.
MilliporeSigma™ Calbiochem™ Porcn Inhibitor IV, LGK974
A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC50 from 50 pM to 1.1 nM).
MilliporeSigma™ Calbiochem™ Purmorphamine
A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 μM).
MilliporeSigma™ Calbiochem™ InSolution™ Purmorphamine
Purmorphamine is a cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells.
MilliporeSigma™ Calbiochem™ Protease Inhibitor Cocktail Set III, EDTA-Free
Protease inhibitor cocktail III, EDTA-free for inhibiting aspartic, cysteine, and serine proteases as well as aminopeptidases in mammalian cells and tissues.
MilliporeSigma™ Calbiochem™ RAD51-Stimulatory Compound-1, RS-1
A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis.
MilliporeSigma™ Calbiochem™ SANT-1
A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.
MilliporeSigma™ Calbiochem™ Ro-31-8220
A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC50 = 10 nM) over CaM kinase II (IC50 = 17 μM) and protein kinase A (IC50 = 900 nM).
MilliporeSigma™ Calbiochem™ Spermidine, Trihydrochloride
Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.
MilliporeSigma™ Calbiochem™ Shikonin
A naphthoquinone found in the Chinese herb Shiunko.
MilliporeSigma™ Calbiochem™ γ-Secretase Inhibitor XXI, Compound E
This g-secretase inhibitor, CAS 209986-17-4, is a cell-permeable, potent, selective, non-transition-state analog inhibitor of γ-secretase and Notch processing. Lowers Aβ levels in APP transgenic mice.
MilliporeSigma™ Calbiochem™ γ-Secretase Substrate, Fluorogenic
An internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase.
MilliporeSigma™ Calbiochem™ Calpain Substrate II, Fluorogenic
Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2.
MilliporeSigma™ Calbiochem™ W-5, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 μM).